Karyomegalic interstitial nephritis in a renal allograft
نویسندگان
چکیده
منابع مشابه
Karyomegalic Interstitial Nephritis
Karyomegalic interstitial nephritis is a rare cause of hereditary chronic interstitial nephritis, described for the first time over 40 years ago.A 36-year-old woman, of Turkish origin, presented with chronic kidney disease and high blood pressure. She had a history of recurrent upper respiratory tract infections but no familial history of nephropathy. Physical examination was unremarkable. Labo...
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The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defective (Fan1(nd/nd)) mice develop a mild form of KIN. The karyomegalic nuclei from Fan1(nd/nd) kidney...
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Background: Granulomatous interstitial nephritis (GIN) is uncommon in native kidneys, and descriptions in allografts are few. We report clinical and pathologic findings in 22 allograft recipients with GIN identified in renal allograft biopsies and nephrectomies. Methods: Renal allografts with GIN were retrieved from the pathology files of two academic medical centers. Available clinical and pat...
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Viral infections are an important complication of solid organ transplantation. Although polyoma is the virus that most commonly infects the renal allograft, adenoviral infections are also reported. We describe the clinical and pathologic findings in a patient with adenoviral infection associated with acute rejection of the renal allograft. The pathologic findings of adenovirus infection usually...
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Drug-induced acute interstitial nephritis (DI-AIN) is a common cause of AKI and leading to CKD and ESRD Although any drug can potentially cause DI-AIN, antibiotics, non-steroidal anti-inflammatory drugs and proton pump inhibitors are the most common culprits. In the present study, we report a 9-year-old child with drug-induced interstitial nephritis (cefotaxime, vancomycin, and acyclovir). it s...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2018
ISSN: 1600-6135,1600-6143
DOI: 10.1111/ajt.15035